Metocurini Iodidum
Metocurini Iodidum Brand names, Metocurini Iodidum Analogs
Metocurini Iodidum Brand Names Mixture
- No information avaliable
Metocurini Iodidum Chemical_Formula
C23H31NO7
Metocurini Iodidum RX_link
http://www.rxlist.com/cgi/generic3/cellcept.htm
Metocurini Iodidum fda sheet
Metocurini Iodidum msds (material safety sheet)
Metocurini Iodidum Synthesis Reference
No information avaliable
Metocurini Iodidum Molecular Weight
469.955 g/mol
Metocurini Iodidum Melting Point
No information avaliable
Metocurini Iodidum H2O Solubility
Slightly soluble (43 mg/mL at pH 7.4)
Metocurini Iodidum State
Solid
Metocurini Iodidum LogP
2.424
Metocurini Iodidum Dosage Forms
Capsule (250mg); Tablet (500 mg); Powder for solution (200 mg/mL constituted)
Metocurini Iodidum Indication
For the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. CellCept should be used concomitantly with cyclosporine and corticosteroids.
Metocurini Iodidum Pharmacology
Mycophenolate mofetil is a prodrug of mycophenolic acid, an antibiotic substance derived from Penicillium stoloniferum. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites.
Metocurini Iodidum Absorption
Rapidly absorbed following oral administration. In 12 healthy volunteers, the mean absolute bioavailability of oral mycophenolate mofetil relative to intravenous mycophenolate mofetil (based on MPA AUC) was 94%. Food (27 g fat, 650 calories) has no effect on the extent of absorption (MPA AUC) of mycophenolate mofetil.
Metocurini Iodidum side effects and Toxicity
Oral (LD50): Acute: 352 mg/kg [Rat], 1000 mg/kg [Mouse], and >6000 mg/kg [Rabbit]. Possible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.
Metocurini Iodidum Patient Information
No information avaliable
Metocurini Iodidum Organisms Affected
Humans and other mammals
