Metaxalone
Brand names,
Metaxalone
Analogs
Metaxalone
Brand Names Mixture
Metaxalone
Chemical_Formula
C12H15NO3
Metaxalone
RX_link
http://www.rxlist.com/cgi/generic/metax.htm
Metaxalone
fda sheet
Metaxalone
msds (material safety sheet)
Metaxalone
Synthesis Reference
No information avaliable
Metaxalone
Molecular Weight
221.252 g/mol
Metaxalone
Melting Point
122 oC
Metaxalone
H2O Solubility
No information avaliable
Metaxalone
State
Solid
Metaxalone
LogP
1.603
Metaxalone
Dosage Forms
Tablets (400 mg round, pale rose tablet and an 800 mg oval, pink scored tablet)
Metaxalone
Indication
For the treatment of painful musculoskeletal conditions
Metaxalone
Pharmacology
Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.
Metaxalone
Absorption
The absolute bioavailability of metaxalone from Skelaxin tablets is not known.
Metaxalone
side effects and Toxicity
LD50=775mg/kg (Rat, oral); LD50=1690 mg/kg (Mouse, oral). When determining the LD50 in rats and mice, progressive sedation, hypnosis and finally respiratoryfailure were noted as the dosage increased. In dogs, no LD50 could be determined as the higher doses produced an emetic action in 15 to 30 minutes.
Metaxalone
Patient Information
Patient Information:
Use Metaxalone with caution. It may affect driving, operating machinery or other hazarous activities. Metaxalone may increase the effects of alcohol
and other central nervous system depressants.
If you have liver problems or you are breast feeding, discuss with your doctor about the risks of taking the Metaxalone.
Metaxalone
Organisms Affected
Humans and other mammals