Mantadine

Mantadine Brand names, Mantadine Analogs

Mantadine Brand Names Mixture

No information avaliable

Mantadine Chemical_Formula

C₁₀H₁₇N

Mantadine RX_link

http://www.rxlist.com/cgi/generic3/amantadine.htm

Mantadine fda sheet

Mantadine FDA

Mantadine msds (material safety sheet)

Mantadine MSDS

Mantadine Synthesis Reference

No information avaliable

Mantadine Molecular Weight

151.249 g/mol

Mantadine Melting Point

180 ^oC

Mantadine H₂O Solubility

6290 mg/L (freely soluble)

Mantadine State

Solid

Mantadine LogP

1.903

Mantadine Dosage Forms

Capsule (100mg) and syrup

Mantadine Indication

For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.

Mantadine Pharmacology

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance). It is a derivate of adamantane, like a similar drug rimantadine. The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. It has been shown to cause an increase in dopamine release in the animal brain, and does not possess anticholinergic activity.

Mantadine Absorption

Amantadine is well absorbed orally from the gastrointestinal tract.

Mantadine side effects and Toxicity

Deaths have been reported from overdose with amantadine. The lowest reported acute lethal dose was 2 grams. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Pulmonary edema and respiratory distress (including ARDS) have been reported. Renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur. Central nervous system effects that have been reported include insomnia, anxiety, aggressive behavior, hypertonia, hyperkinesia, tremor, confusion, disorientation, depersonalization, fear, delirium, hallucination, psychotic reactions, lethargy, somnolence and coma. Seizures may be exacerbated in patients with prior history of seizure disorders. Hyperthermia has also been observed in cases where a drug overdose has occurred.

Mantadine Patient Information