Amantadine Base

Amantadine Base Brand names, Amantadine Base Analogs

Amantadine Base Brand Names Mixture

No information avaliable

Amantadine Base Chemical_Formula

C₁₀H₁₇N

Amantadine Base RX_link

http://www.rxlist.com/cgi/generic3/amantadine.htm

Amantadine Base fda sheet

Amantadine_Base FDA

Amantadine Base msds (material safety sheet)

Amantadine_Base MSDS

Amantadine Base Synthesis Reference

No information avaliable

Amantadine Base Molecular Weight

151.249 g/mol

Amantadine Base Melting Point

180 ^oC

Amantadine Base H₂O Solubility

6290 mg/L (freely soluble)

Amantadine Base State

Solid

Amantadine Base LogP

1.903

Amantadine Base Dosage Forms

Capsule (100mg) and syrup

Amantadine Base Indication

For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.

Amantadine Base Pharmacology

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance). It is a derivate of adamantane, like a similar drug rimantadine. The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. It has been shown to cause an increase in dopamine release in the animal brain, and does not possess anticholinergic activity.

Amantadine Base Absorption

Amantadine is well absorbed orally from the gastrointestinal tract.

Amantadine Base side effects and Toxicity

Deaths have been reported from overdose with amantadine. The lowest reported acute lethal dose was 2 grams. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Pulmonary edema and respiratory distress (including ARDS) have been reported. Renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur. Central nervous system effects that have been reported include insomnia, anxiety, aggressive behavior, hypertonia, hyperkinesia, tremor, confusion, disorientation, depersonalization, fear, delirium, hallucination, psychotic reactions, lethargy, somnolence and coma. Seizures may be exacerbated in patients with prior history of seizure disorders. Hyperthermia has also been observed in cases where a drug overdose has occurred.

Amantadine Base Patient Information