Gen-Amantadine

• Analgesics, Non-Narcotic
• Antiparkinson Agents
• Antiviral Agents
• Dopamine Agents
• ATC:N04BB01

• Adamantamine
• Adamantanamine
• Adamantylamine
• Amantadine Base
• Amantadine HCL
• Amantidine
• Aminoadamantane
• Endantadine
• Gen-Amantadine
• Mantadine
• Pk-Merz
• Symadine
• Symmetrel

• No information avaliable

C₁₀H₁₇N

http://www.rxlist.com/cgi/generic3/amantadine.htm

Gen-Amantadine FDA

Gen-Amantadine MSDS

No information avaliable

151.249 g/mol

180 ^oC

6290 mg/L (freely soluble)

Solid

1.903

Capsule (100mg) and syrup

For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance). It is a derivate of adamantane, like a similar drug rimantadine. The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. It has been shown to cause an increase in dopamine release in the animal brain, and does not possess anticholinergic activity.

Amantadine is well absorbed orally from the gastrointestinal tract.

Deaths have been reported from overdose with amantadine. The lowest reported acute lethal dose was 2 grams. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Pulmonary edema and respiratory distress (including ARDS) have been reported. Renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur. Central nervous system effects that have been reported include insomnia, anxiety, aggressive behavior, hypertonia, hyperkinesia, tremor, confusion, disorientation, depersonalization, fear, delirium, hallucination, psychotic reactions, lethargy, somnolence and coma. Seizures may be exacerbated in patients with prior history of seizure disorders. Hyperthermia has also been observed in cases where a drug overdose has occurred.

No information avaliable

Humans, other mammals and virus