Amantadine HCL

Amantadine HCL Brand names, Amantadine HCL Analogs

Amantadine HCL Brand Names Mixture

No information avaliable

Amantadine HCL Chemical_Formula

C₁₀H₁₇N

Amantadine HCL RX_link

http://www.rxlist.com/cgi/generic3/amantadine.htm

Amantadine HCL fda sheet

Amantadine_HCL FDA

Amantadine HCL msds (material safety sheet)

Amantadine_HCL MSDS

Amantadine HCL Synthesis Reference

No information avaliable

Amantadine HCL Molecular Weight

151.249 g/mol

Amantadine HCL Melting Point

180 ^oC

Amantadine HCL H₂O Solubility

6290 mg/L (freely soluble)

Amantadine HCL State

Solid

Amantadine HCL LogP

1.903

Amantadine HCL Dosage Forms

Capsule (100mg) and syrup

Amantadine HCL Indication

For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.

Amantadine HCL Pharmacology

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance). It is a derivate of adamantane, like a similar drug rimantadine. The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. It has been shown to cause an increase in dopamine release in the animal brain, and does not possess anticholinergic activity.

Amantadine HCL Absorption

Amantadine is well absorbed orally from the gastrointestinal tract.

Amantadine HCL side effects and Toxicity

Deaths have been reported from overdose with amantadine. The lowest reported acute lethal dose was 2 grams. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Pulmonary edema and respiratory distress (including ARDS) have been reported. Renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur. Central nervous system effects that have been reported include insomnia, anxiety, aggressive behavior, hypertonia, hyperkinesia, tremor, confusion, disorientation, depersonalization, fear, delirium, hallucination, psychotic reactions, lethargy, somnolence and coma. Seizures may be exacerbated in patients with prior history of seizure disorders. Hyperthermia has also been observed in cases where a drug overdose has occurred.

Amantadine HCL Patient Information