Levallorphan

Levallorphan Brand names, Levallorphan Analogs

Levallorphan Brand Names Mixture

No information avaliable

Levallorphan Chemical_Formula

C₁₉H₂₅NO

Levallorphan RX_link

No information avaliable

Levallorphan fda sheet

Levallorphan msds (material safety sheet)

Levallorphan Synthesis Reference

Schnider, et al., Helv. Chim. Acta. 34, 2211 (1951)

Levallorphan Molecular Weight

283.408 g/mol

Levallorphan Melting Point

181 ^oC

Levallorphan H₂O Solubility

633 mg/L

Levallorphan State

Solid

Levallorphan LogP

4.546

Levallorphan Dosage Forms

Solution for injection (intramuscular, subcutaneous or intravenous)

Levallorphan Indication

For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.

Levallorphan Pharmacology

Levallorphan, an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallorphan differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallorphan prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Levallorphan Absorption

Rapidly absorbed.

Levallorphan side effects and Toxicity

Oral, rat LD₅₀: 109±4 mg/kg

Levallorphan Patient Information