Levallorphan

• Analgesic Antagonists
• Morphine Antidotes
• Antinarcotic Agents
• Narcotic Antagonists

• Levallofano [Dcit]
• Levallorphane [Inn-French]
• Levallorphanum [Inn-Latin]
• Levalorfano [Inn-Spanish]
• Lorfan
• Naloxiphan

• No information avaliable

C₁₉H₂₅NO

No information avaliable

Schnider, et al., Helv. Chim. Acta. 34, 2211 (1951)

283.408 g/mol

181 ^oC

633 mg/L

Solid

4.546

Solution for injection (intramuscular, subcutaneous or intravenous)

For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.

Levallorphan, an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallorphan differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallorphan prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Rapidly absorbed.

Oral, rat LD₅₀: 109±4 mg/kg

No information avaliable

Humans and other mammals