Levallorphanum [Inn-Latin]

Levallorphanum [Inn-Latin] Brand names, Levallorphanum [Inn-Latin] Analogs

Levallorphanum [Inn-Latin] Brand Names Mixture

No information avaliable

Levallorphanum [Inn-Latin] Chemical_Formula

C₁₉H₂₅NO

Levallorphanum [Inn-Latin] RX_link

No information avaliable

Levallorphanum [Inn-Latin] fda sheet

Levallorphanum [Inn-Latin] msds (material safety sheet)

Levallorphanum [Inn-Latin] Synthesis Reference

Schnider, et al., Helv. Chim. Acta. 34, 2211 (1951)

Levallorphanum [Inn-Latin] Molecular Weight

283.408 g/mol

Levallorphanum [Inn-Latin] Melting Point

181 ^oC

Levallorphanum [Inn-Latin] H₂O Solubility

633 mg/L

Levallorphanum [Inn-Latin] State

Solid

Levallorphanum [Inn-Latin] LogP

4.546

Levallorphanum [Inn-Latin] Dosage Forms

Solution for injection (intramuscular, subcutaneous or intravenous)

Levallorphanum [Inn-Latin] Indication

For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.

Levallorphanum [Inn-Latin] Pharmacology

Levallorphan, an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallorphan differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallorphan prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Levallorphanum [Inn-Latin] Absorption

Rapidly absorbed.

Levallorphanum [Inn-Latin] side effects and Toxicity

Oral, rat LD₅₀: 109±4 mg/kg

Levallorphanum [Inn-Latin] Patient Information