Naloxiphan

Naloxiphan Brand names, Naloxiphan Analogs

Naloxiphan Brand Names Mixture

No information avaliable

Naloxiphan Chemical_Formula

C₁₉H₂₅NO

Naloxiphan RX_link

No information avaliable

Naloxiphan fda sheet

Naloxiphan msds (material safety sheet)

Naloxiphan Synthesis Reference

Schnider, et al., Helv. Chim. Acta. 34, 2211 (1951)

Naloxiphan Molecular Weight

283.408 g/mol

Naloxiphan Melting Point

181 ^oC

Naloxiphan H₂O Solubility

633 mg/L

Naloxiphan State

Solid

Naloxiphan LogP

4.546

Naloxiphan Dosage Forms

Solution for injection (intramuscular, subcutaneous or intravenous)

Naloxiphan Indication

For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.

Naloxiphan Pharmacology

Levallorphan, an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallorphan differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallorphan prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.

Naloxiphan Absorption

Rapidly absorbed.

Naloxiphan side effects and Toxicity

Oral, rat LD₅₀: 109±4 mg/kg

Naloxiphan Patient Information