L-Histidine (JAN/USP)
L-Histidine (JAN/USP) Brand names, L-Histidine (JAN/USP) Analogs
- (S)-4-(2-Amino-2-carboxyethyl)imidazole
- (S)-Histidine
- (S)-a-Amino-1H-imidazole-4-propanoic acid
- (S)-alpha-Amino-1H-imidazole-4-propionic acid
- 1H-Imidazole-4-alanine, (S)-
- 1H-Imidazole-4-propanoic acid, a-amino-, (S)-
- Glyoxaline-5-alanine
- Histidine
- Histidine, L-
- L-(-)-Histidine
- L-Alanine, 3-(1H-imidazol-4-yl)-
- L-Histidine
- L-Histidine (JAN/USP)
L-Histidine (JAN/USP) Brand Names Mixture
- No information avaliable
L-Histidine (JAN/USP) Chemical_Formula
C6H9N3O2
L-Histidine (JAN/USP) RX_link
No information avaliable
L-Histidine (JAN/USP) fda sheet
L-Histidine (JAN/USP) msds (material safety sheet)
L-Histidine (JAN/USP) Synthesis Reference
No information avaliable
L-Histidine (JAN/USP) Molecular Weight
155.15 g/mol
L-Histidine (JAN/USP) Melting Point
282 oC
L-Histidine (JAN/USP) H2O Solubility
No information avaliable
L-Histidine (JAN/USP) State
Solid, white crystals
L-Histidine (JAN/USP) LogP
-3.461
L-Histidine (JAN/USP) Dosage Forms
Capsules, powder and tablets
L-Histidine (JAN/USP) Indication
The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
L-Histidine (JAN/USP) Pharmacology
Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers & anemia. A deficiency can cause poor hearing.
L-Histidine (JAN/USP) Absorption
Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
L-Histidine (JAN/USP) side effects and Toxicity
ORL-RAT LD50 > 15000 mg kg-1, IPR-RAT LD50 > 8000 mg kg-1, ORL-MUS LD50 > 15000 mg kg-1, IVN-MUS LD50 > 2000 mg kg-1; Mild gastrointestinal side effects.
L-Histidine (JAN/USP) Patient Information
L-histidine supplements should be avoided by children, pregnant women and nursing mothers. Those with allergies or peptic ulcer disease should only use L-histidine supplements under strict medical supervision. Although there are no reports of adverse events in these groups, increased histamine production from L-histidine might negatively affect those with these conditions.
L-Histidine (JAN/USP) Organisms Affected
Humans and other mammals
