Histidine
Brand names,
Histidine
Analogs
Histidine
Brand Names Mixture
Histidine
Chemical_Formula
C6H9N3O2
Histidine
RX_link
No information avaliable
Histidine
fda sheet
Histidine
msds (material safety sheet)
Histidine
Synthesis Reference
No information avaliable
Histidine
Molecular Weight
155.15 g/mol
Histidine
Melting Point
282 oC
Histidine
H2O Solubility
No information avaliable
Histidine
State
Solid, white crystals
Histidine
LogP
-3.461
Histidine
Dosage Forms
Capsules, powder and tablets
Histidine
Indication
The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
Histidine
Pharmacology
Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers & anemia. A deficiency can cause poor hearing.
Histidine
Absorption
Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
Histidine
side effects and Toxicity
ORL-RAT LD50 > 15000 mg kg-1, IPR-RAT LD50 > 8000 mg kg-1, ORL-MUS LD50 > 15000 mg kg-1, IVN-MUS LD50 > 2000 mg kg-1; Mild gastrointestinal side effects.
Histidine
Patient Information
L-histidine supplements should be avoided by children, pregnant women and nursing mothers. Those with allergies or peptic ulcer disease should only use L-histidine supplements under strict medical supervision. Although there are no reports of adverse events in these groups, increased histamine production from L-histidine might negatively affect those with these conditions.
Histidine
Organisms Affected
Humans and other mammals