1H-Imidazole-4-alanine, (S)-
Brand names,
1H-Imidazole-4-alanine, (S)-
Analogs
1H-Imidazole-4-alanine, (S)-
Brand Names Mixture
1H-Imidazole-4-alanine, (S)-
Chemical_Formula
C6H9N3O2
1H-Imidazole-4-alanine, (S)-
RX_link
No information avaliable
1H-Imidazole-4-alanine, (S)-
fda sheet
1H-Imidazole-4-alanine, (S)-
msds (material safety sheet)
1H-Imidazole-4-alanine, (S)-
Synthesis Reference
No information avaliable
1H-Imidazole-4-alanine, (S)-
Molecular Weight
155.15 g/mol
1H-Imidazole-4-alanine, (S)-
Melting Point
282 oC
1H-Imidazole-4-alanine, (S)-
H2O Solubility
No information avaliable
1H-Imidazole-4-alanine, (S)-
State
Solid, white crystals
1H-Imidazole-4-alanine, (S)-
LogP
-3.461
1H-Imidazole-4-alanine, (S)-
Dosage Forms
Capsules, powder and tablets
1H-Imidazole-4-alanine, (S)-
Indication
The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
1H-Imidazole-4-alanine, (S)-
Pharmacology
Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers & anemia. A deficiency can cause poor hearing.
1H-Imidazole-4-alanine, (S)-
Absorption
Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
1H-Imidazole-4-alanine, (S)-
side effects and Toxicity
ORL-RAT LD50 > 15000 mg kg-1, IPR-RAT LD50 > 8000 mg kg-1, ORL-MUS LD50 > 15000 mg kg-1, IVN-MUS LD50 > 2000 mg kg-1; Mild gastrointestinal side effects.
1H-Imidazole-4-alanine, (S)-
Patient Information
L-histidine supplements should be avoided by children, pregnant women and nursing mothers. Those with allergies or peptic ulcer disease should only use L-histidine supplements under strict medical supervision. Although there are no reports of adverse events in these groups, increased histamine production from L-histidine might negatively affect those with these conditions.
1H-Imidazole-4-alanine, (S)-
Organisms Affected
Humans and other mammals