(S)-alpha-Amino-1H-imidazole-4-propionic acid
Brand names,
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Analogs
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Brand Names Mixture
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Chemical_Formula
C6H9N3O2
(S)-alpha-Amino-1H-imidazole-4-propionic acid
RX_link
No information avaliable
(S)-alpha-Amino-1H-imidazole-4-propionic acid
fda sheet
(S)-alpha-Amino-1H-imidazole-4-propionic acid
msds (material safety sheet)
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Synthesis Reference
No information avaliable
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Molecular Weight
155.15 g/mol
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Melting Point
282 oC
(S)-alpha-Amino-1H-imidazole-4-propionic acid
H2O Solubility
No information avaliable
(S)-alpha-Amino-1H-imidazole-4-propionic acid
State
Solid, white crystals
(S)-alpha-Amino-1H-imidazole-4-propionic acid
LogP
-3.461
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Dosage Forms
Capsules, powder and tablets
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Indication
The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Pharmacology
Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers & anemia. A deficiency can cause poor hearing.
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Absorption
Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
(S)-alpha-Amino-1H-imidazole-4-propionic acid
side effects and Toxicity
ORL-RAT LD50 > 15000 mg kg-1, IPR-RAT LD50 > 8000 mg kg-1, ORL-MUS LD50 > 15000 mg kg-1, IVN-MUS LD50 > 2000 mg kg-1; Mild gastrointestinal side effects.
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Patient Information
L-histidine supplements should be avoided by children, pregnant women and nursing mothers. Those with allergies or peptic ulcer disease should only use L-histidine supplements under strict medical supervision. Although there are no reports of adverse events in these groups, increased histamine production from L-histidine might negatively affect those with these conditions.
(S)-alpha-Amino-1H-imidazole-4-propionic acid
Organisms Affected
Humans and other mammals