Itraconazole
Itraconazole Brand names, Itraconazole Analogs
Itraconazole Brand Names Mixture
- No information avaliable
Itraconazole Chemical_Formula
C35H38Cl2N8O4
Itraconazole RX_link
http://www.rxlist.com/cgi/generic/itraconazole.htm
Itraconazole fda sheet
Itraconazole msds (material safety sheet)
Itraconazole Synthesis Reference
No information avaliable
Itraconazole Molecular Weight
705.633 g/mol
Itraconazole Melting Point
166.2 oC
Itraconazole H2O Solubility
Insoluble
Itraconazole State
Solid
Itraconazole LogP
6.939
Itraconazole Dosage Forms
Capsules (100 mg); Liquid solution
Itraconazole Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Itraconazole Pharmacology
Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Itraconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.
Itraconazole Absorption
The absolute oral bioavailability of itraconazole is 55%, and is maximal when taken with a full meal.
Itraconazole side effects and Toxicity
No significant lethality was observed when itraconazole was administered orally to mice and rats at dosage levels of 320 mg/kg or to dogs at 200 mg/kg.
Itraconazole Patient Information
No information avaliable
Itraconazole Organisms Affected
Fungi, yeast and protozoans
