Itraconazole en es it fr

Itraconazole Brand names, Itraconazole Analogs

Itraconazole Brand Names Mixture

  • No information avaliable

Itraconazole Chemical_Formula


Itraconazole RX_link

Itraconazole fda sheet

Itraconazole FDA

Itraconazole msds (material safety sheet)

Itraconazole MSDS

Itraconazole Synthesis Reference

No information avaliable

Itraconazole Molecular Weight

705.633 g/mol

Itraconazole Melting Point

166.2 oC

Itraconazole H2O Solubility


Itraconazole State


Itraconazole LogP


Itraconazole Dosage Forms

Capsules (100 mg); Liquid solution

Itraconazole Indication

For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

Itraconazole Pharmacology

Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Itraconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans.

Itraconazole Absorption

The absolute oral bioavailability of itraconazole is 55%, and is maximal when taken with a full meal.

Itraconazole side effects and Toxicity

No significant lethality was observed when itraconazole was administered orally to mice and rats at dosage levels of 320 mg/kg or to dogs at 200 mg/kg.

Itraconazole Patient Information

No information avaliable

Itraconazole Organisms Affected

Fungi, yeast and protozoans