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Irbesartan Brand names, Irbesartan Analogs

Irbesartan Brand Names Mixture

  • Avalide 150/12.5 mg (Hydrochlorothiazide + Irbesartan)
  • Avalide 300/12.5 mg (Hydrochlorothiazide + Irbesartan)

Irbesartan Chemical_Formula


Irbesartan RX_link

Irbesartan fda sheet

Irbesartan FDA

Irbesartan msds (material safety sheet)

Irbesartan MSDS

Irbesartan Synthesis Reference

C. Bernhart et al.; U.S. Pat. 5,270,317 (1993)

Irbesartan Molecular Weight

428.53 g/mol

Irbesartan Melting Point

180-181 oC

Irbesartan H2O Solubility

No information avaliable

Irbesartan State


Irbesartan LogP


Irbesartan Dosage Forms

Tablet (oral)

Irbesartan Indication

For the treatment of hypertension, and for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension.

Irbesartan Pharmacology

Irbesartan is a specific competitive antagonist of AT1 receptors with a much greater affinity (more than 8500-fold) for the AT1 receptor than for the AT2 receptor and no agonist activity.

Irbesartan Absorption

Rapid and complete with an average absolute bioavailability of 60-80%. Food has no affect on bioavailability.

Irbesartan side effects and Toxicity

Hypotension and tachycardia; bradycardia might also occur from overdose, LD50=mg/kg(orally in rat)

Irbesartan Patient Information

Pregnancy: Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.

Irbesartan Organisms Affected

Humans and other mammals