Irbesartan
Irbesartan Brand names, Irbesartan Analogs
Irbesartan Brand Names Mixture
- Avalide 150/12.5 mg (Hydrochlorothiazide + Irbesartan)
- Avalide 300/12.5 mg (Hydrochlorothiazide + Irbesartan)
Irbesartan Chemical_Formula
C25H28N6O
Irbesartan RX_link
http://www.rxlist.com/cgi/generic/irbesart.htm
Irbesartan fda sheet
Irbesartan msds (material safety sheet)
Irbesartan Synthesis Reference
C. Bernhart et al.; U.S. Pat. 5,270,317 (1993)
Irbesartan Molecular Weight
428.53 g/mol
Irbesartan Melting Point
180-181 oC
Irbesartan H2O Solubility
No information avaliable
Irbesartan State
Solid
Irbesartan LogP
5.379
Irbesartan Dosage Forms
Tablet (oral)
Irbesartan Indication
For the treatment of hypertension, and for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension.
Irbesartan Pharmacology
Irbesartan is a specific competitive antagonist of AT1 receptors with a much greater affinity (more than 8500-fold) for the AT1 receptor than for the AT2 receptor and no agonist activity.
Irbesartan Absorption
Rapid and complete with an average absolute bioavailability of 60-80%. Food has no affect on bioavailability.
Irbesartan side effects and Toxicity
Hypotension and tachycardia; bradycardia might also occur from overdose, LD50=mg/kg(orally in rat)
Irbesartan Patient Information
Pregnancy: Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.
Irbesartan Organisms Affected
Humans and other mammals
