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Avapro Brand names, Avapro Analogs

Avapro Brand Names Mixture

  • Avalide 150/12.5 mg (Hydrochlorothiazide + Irbesartan)
  • Avalide 300/12.5 mg (Hydrochlorothiazide + Irbesartan)

Avapro Chemical_Formula


Avapro RX_link


Avapro fda sheet

Avapro FDA

Avapro msds (material safety sheet)

Avapro MSDS

Avapro Synthesis Reference

C. Bernhart et al.; U.S. Pat. 5,270,317 (1993)

Avapro Molecular Weight

428.53 g/mol

Avapro Melting Point

180-181 oC

Avapro H2O Solubility

No information avaliable

Avapro State


Avapro LogP


Avapro Dosage Forms

Tablet (oral)

Avapro Indication

For the treatment of hypertension, and for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension.

Avapro Pharmacology

Irbesartan is a specific competitive antagonist of AT1 receptors with a much greater affinity (more than 8500-fold) for the AT1 receptor than for the AT2 receptor and no agonist activity.

Avapro Absorption

Rapid and complete with an average absolute bioavailability of 60-80%. Food has no affect on bioavailability.

Avapro side effects and Toxicity

Hypotension and tachycardia; bradycardia might also occur from overdose, LD50=mg/kg(orally in rat)

Avapro Patient Information

Pregnancy: Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.

Avapro Organisms Affected

Humans and other mammals