Irbesarran
Irbesarran Brand names, Irbesarran Analogs
Irbesarran Brand Names Mixture
- Avalide 150/12.5 mg (Hydrochlorothiazide + Irbesartan)
- Avalide 300/12.5 mg (Hydrochlorothiazide + Irbesartan)
Irbesarran Chemical_Formula
C25H28N6O
Irbesarran RX_link
http://www.rxlist.com/cgi/generic/irbesart.htm
Irbesarran fda sheet
Irbesarran msds (material safety sheet)
Irbesarran Synthesis Reference
C. Bernhart et al.; U.S. Pat. 5,270,317 (1993)
Irbesarran Molecular Weight
428.53 g/mol
Irbesarran Melting Point
180-181 oC
Irbesarran H2O Solubility
No information avaliable
Irbesarran State
Solid
Irbesarran LogP
5.379
Irbesarran Dosage Forms
Tablet (oral)
Irbesarran Indication
For the treatment of hypertension, and for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension.
Irbesarran Pharmacology
Irbesartan is a specific competitive antagonist of AT1 receptors with a much greater affinity (more than 8500-fold) for the AT1 receptor than for the AT2 receptor and no agonist activity.
Irbesarran Absorption
Rapid and complete with an average absolute bioavailability of 60-80%. Food has no affect on bioavailability.
Irbesarran side effects and Toxicity
Hypotension and tachycardia; bradycardia might also occur from overdose, LD50=mg/kg(orally in rat)
Irbesarran Patient Information
Pregnancy: Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.
Irbesarran Organisms Affected
Humans and other mammals
