Lrbesartan
Lrbesartan Brand names, Lrbesartan Analogs
Lrbesartan Brand Names Mixture
- Avalide 150/12.5 mg (Hydrochlorothiazide + Irbesartan)
- Avalide 300/12.5 mg (Hydrochlorothiazide + Irbesartan)
Lrbesartan Chemical_Formula
C25H28N6O
Lrbesartan RX_link
http://www.rxlist.com/cgi/generic/irbesart.htm
Lrbesartan fda sheet
Lrbesartan msds (material safety sheet)
Lrbesartan Synthesis Reference
C. Bernhart et al.; U.S. Pat. 5,270,317 (1993)
Lrbesartan Molecular Weight
428.53 g/mol
Lrbesartan Melting Point
180-181 oC
Lrbesartan H2O Solubility
No information avaliable
Lrbesartan State
Solid
Lrbesartan LogP
5.379
Lrbesartan Dosage Forms
Tablet (oral)
Lrbesartan Indication
For the treatment of hypertension, and for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension.
Lrbesartan Pharmacology
Irbesartan is a specific competitive antagonist of AT1 receptors with a much greater affinity (more than 8500-fold) for the AT1 receptor than for the AT2 receptor and no agonist activity.
Lrbesartan Absorption
Rapid and complete with an average absolute bioavailability of 60-80%. Food has no affect on bioavailability.
Lrbesartan side effects and Toxicity
Hypotension and tachycardia; bradycardia might also occur from overdose, LD50=mg/kg(orally in rat)
Lrbesartan Patient Information
Pregnancy: Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.
Lrbesartan Organisms Affected
Humans and other mammals
