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Lrbesartan Brand names, Lrbesartan Analogs

Lrbesartan Brand Names Mixture

  • Avalide 150/12.5 mg (Hydrochlorothiazide + Irbesartan)
  • Avalide 300/12.5 mg (Hydrochlorothiazide + Irbesartan)

Lrbesartan Chemical_Formula


Lrbesartan RX_link

Lrbesartan fda sheet

Lrbesartan FDA

Lrbesartan msds (material safety sheet)

Lrbesartan MSDS

Lrbesartan Synthesis Reference

C. Bernhart et al.; U.S. Pat. 5,270,317 (1993)

Lrbesartan Molecular Weight

428.53 g/mol

Lrbesartan Melting Point

180-181 oC

Lrbesartan H2O Solubility

No information avaliable

Lrbesartan State


Lrbesartan LogP


Lrbesartan Dosage Forms

Tablet (oral)

Lrbesartan Indication

For the treatment of hypertension, and for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension.

Lrbesartan Pharmacology

Irbesartan is a specific competitive antagonist of AT1 receptors with a much greater affinity (more than 8500-fold) for the AT1 receptor than for the AT2 receptor and no agonist activity.

Lrbesartan Absorption

Rapid and complete with an average absolute bioavailability of 60-80%. Food has no affect on bioavailability.

Lrbesartan side effects and Toxicity

Hypotension and tachycardia; bradycardia might also occur from overdose, LD50=mg/kg(orally in rat)

Lrbesartan Patient Information

Pregnancy: Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.

Lrbesartan Organisms Affected

Humans and other mammals