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Avalide Brand names, Avalide Analogs

Avalide Brand Names Mixture

  • Avalide 150/12.5 mg (Hydrochlorothiazide + Irbesartan)
  • Avalide 300/12.5 mg (Hydrochlorothiazide + Irbesartan)

Avalide Chemical_Formula


Avalide RX_link


Avalide fda sheet

Avalide FDA

Avalide msds (material safety sheet)

Avalide MSDS

Avalide Synthesis Reference

C. Bernhart et al.; U.S. Pat. 5,270,317 (1993)

Avalide Molecular Weight

428.53 g/mol

Avalide Melting Point

180-181 oC

Avalide H2O Solubility

No information avaliable

Avalide State


Avalide LogP


Avalide Dosage Forms

Tablet (oral)

Avalide Indication

For the treatment of hypertension, and for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension.

Avalide Pharmacology

Irbesartan is a specific competitive antagonist of AT1 receptors with a much greater affinity (more than 8500-fold) for the AT1 receptor than for the AT2 receptor and no agonist activity.

Avalide Absorption

Rapid and complete with an average absolute bioavailability of 60-80%. Food has no affect on bioavailability.

Avalide side effects and Toxicity

Hypotension and tachycardia; bradycardia might also occur from overdose, LD50=mg/kg(orally in rat)

Avalide Patient Information

Pregnancy: Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.

Avalide Organisms Affected

Humans and other mammals