Gliadel
Gliadel Brand names, Gliadel Analogs
Gliadel Brand Names Mixture
- No information avaliable
Gliadel Chemical_Formula
C5H9Cl2N3O2
Gliadel RX_link
http://www.rxlist.com/cgi/generic3/carmustine.htm
Gliadel fda sheet
Gliadel msds (material safety sheet)
Gliadel Synthesis Reference
Johnston TP et al. J Med Chem 122:669-681(1963).
Gliadel Molecular Weight
214.049 g/mol
Gliadel Melting Point
31 oC
Gliadel H2O Solubility
< 0.1 g/100 mL at 18 °C
Gliadel State
Solid
Gliadel LogP
1.256
Gliadel Dosage Forms
Powder for solution; Wafer
Gliadel Indication
For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Gliadel Pharmacology
Carmustine is one of the nitrosoureas indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in treatment of brain tumors, multiple myeloma, Hodgkin's disease, and non-Hodgkin's lymphomas. Although it is generally agreed that carmustine alkylates DNA and RNA, it is not cross resistant with other alkylators. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.
Gliadel Absorption
5 to 28% bioavailability
Gliadel side effects and Toxicity
The oral LD50s in rat and mouse are 20 mg/kg and 45 mg/kg, respectively. Side effects include leukopenia, thrombocytopenia, nausea. Toxic effects include pulmonary fibrosis (20-0%) and bone marrow toxicity.
Gliadel Patient Information
No information avaliable
Gliadel Organisms Affected
Humans and other mammals
