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Gliadel Brand names, Gliadel Analogs

Gliadel Brand Names Mixture

  • No information avaliable

Gliadel Chemical_Formula


Gliadel RX_link

Gliadel fda sheet

Gliadel msds (material safety sheet)

Gliadel MSDS

Gliadel Synthesis Reference

Johnston TP et al. J Med Chem 122:669-681(1963).

Gliadel Molecular Weight

214.049 g/mol

Gliadel Melting Point

31 oC

Gliadel H2O Solubility

< 0.1 g/100 mL at 18 °C

Gliadel State


Gliadel LogP


Gliadel Dosage Forms

Powder for solution; Wafer

Gliadel Indication

For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.

Gliadel Pharmacology

Carmustine is one of the nitrosoureas indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in treatment of brain tumors, multiple myeloma, Hodgkin's disease, and non-Hodgkin's lymphomas. Although it is generally agreed that carmustine alkylates DNA and RNA, it is not cross resistant with other alkylators. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.

Gliadel Absorption

5 to 28% bioavailability

Gliadel side effects and Toxicity

The oral LD50s in rat and mouse are 20 mg/kg and 45 mg/kg, respectively. Side effects include leukopenia, thrombocytopenia, nausea. Toxic effects include pulmonary fibrosis (20-0%) and bone marrow toxicity.

Gliadel Patient Information

No information avaliable

Gliadel Organisms Affected

Humans and other mammals