Gliadel Wafer
Gliadel Wafer Brand names, Gliadel Wafer Analogs
Gliadel Wafer Brand Names Mixture
- No information avaliable
Gliadel Wafer Chemical_Formula
C5H9Cl2N3O2
Gliadel Wafer RX_link
http://www.rxlist.com/cgi/generic3/carmustine.htm
Gliadel Wafer fda sheet
Gliadel Wafer msds (material safety sheet)
Gliadel Wafer Synthesis Reference
Johnston TP et al. J Med Chem 122:669-681(1963).
Gliadel Wafer Molecular Weight
214.049 g/mol
Gliadel Wafer Melting Point
31 oC
Gliadel Wafer H2O Solubility
< 0.1 g/100 mL at 18 °C
Gliadel Wafer State
Solid
Gliadel Wafer LogP
1.256
Gliadel Wafer Dosage Forms
Powder for solution; Wafer
Gliadel Wafer Indication
For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Gliadel Wafer Pharmacology
Carmustine is one of the nitrosoureas indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in treatment of brain tumors, multiple myeloma, Hodgkin's disease, and non-Hodgkin's lymphomas. Although it is generally agreed that carmustine alkylates DNA and RNA, it is not cross resistant with other alkylators. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.
Gliadel Wafer Absorption
5 to 28% bioavailability
Gliadel Wafer side effects and Toxicity
The oral LD50s in rat and mouse are 20 mg/kg and 45 mg/kg, respectively. Side effects include leukopenia, thrombocytopenia, nausea. Toxic effects include pulmonary fibrosis (20-0%) and bone marrow toxicity.
Gliadel Wafer Patient Information
No information avaliable
Gliadel Wafer Organisms Affected
Humans and other mammals
