Fludura
Brand names,
Fludura
Analogs
Fludura
Brand Names Mixture
Fludura
Chemical_Formula
C10H13FN5O7P
Fludura
RX_link
http://www.rxlist.com/cgi/generic/fludarabine.htm
Fludura
fda sheet
Fludura
msds (material safety sheet)
Fludura
Synthesis Reference
J. A. Montgomery, U.S. pat. 4,210,745 (1980 to U.S. Dept. Health, Education and Welfare)
Fludura
Molecular Weight
365.212 g/mol
Fludura
Melting Point
260 oC
Fludura
H2O Solubility
3.53 mg/ml
Fludura
State
Solid
Fludura
LogP
-0.852
Fludura
Dosage Forms
Tablet; Powder for solution; IV solution
Fludura
Indication
For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Fludura
Pharmacology
Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.
Fludura
Absorption
No information avaliable
Fludura
side effects and Toxicity
No information avaliable
Fludura
Patient Information
Fludura
Organisms Affected
Humans and other mammals