Fludarabine phosphate
Brand names,
Fludarabine phosphate
Analogs
Fludarabine phosphate
Brand Names Mixture
Fludarabine phosphate
Chemical_Formula
C10H13FN5O7P
Fludarabine phosphate
RX_link
http://www.rxlist.com/cgi/generic/fludarabine.htm
Fludarabine phosphate
fda sheet
Fludarabine phosphate
msds (material safety sheet)
Fludarabine phosphate
Synthesis Reference
J. A. Montgomery, U.S. pat. 4,210,745 (1980 to U.S. Dept. Health, Education and Welfare)
Fludarabine phosphate
Molecular Weight
365.212 g/mol
Fludarabine phosphate
Melting Point
260 oC
Fludarabine phosphate
H2O Solubility
3.53 mg/ml
Fludarabine phosphate
State
Solid
Fludarabine phosphate
LogP
-0.852
Fludarabine phosphate
Dosage Forms
Tablet; Powder for solution; IV solution
Fludarabine phosphate
Indication
For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Fludarabine phosphate
Pharmacology
Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.
Fludarabine phosphate
Absorption
No information avaliable
Fludarabine phosphate
side effects and Toxicity
No information avaliable
Fludarabine phosphate
Patient Information
Fludarabine phosphate
Organisms Affected
Humans and other mammals