Fludarabine monophosphate
Brand names,
Fludarabine monophosphate
Analogs
Fludarabine monophosphate
Brand Names Mixture
Fludarabine monophosphate
Chemical_Formula
C10H13FN5O7P
Fludarabine monophosphate
RX_link
http://www.rxlist.com/cgi/generic/fludarabine.htm
Fludarabine monophosphate
fda sheet
Fludarabine monophosphate
msds (material safety sheet)
Fludarabine monophosphate
Synthesis Reference
J. A. Montgomery, U.S. pat. 4,210,745 (1980 to U.S. Dept. Health, Education and Welfare)
Fludarabine monophosphate
Molecular Weight
365.212 g/mol
Fludarabine monophosphate
Melting Point
260 oC
Fludarabine monophosphate
H2O Solubility
3.53 mg/ml
Fludarabine monophosphate
State
Solid
Fludarabine monophosphate
LogP
-0.852
Fludarabine monophosphate
Dosage Forms
Tablet; Powder for solution; IV solution
Fludarabine monophosphate
Indication
For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Fludarabine monophosphate
Pharmacology
Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.
Fludarabine monophosphate
Absorption
No information avaliable
Fludarabine monophosphate
side effects and Toxicity
No information avaliable
Fludarabine monophosphate
Patient Information
Fludarabine monophosphate
Organisms Affected
Humans and other mammals