Flucytosine
Flucytosine Brand names, Flucytosine Analogs
Flucytosine Brand Names Mixture
- No information avaliable
Flucytosine Chemical_Formula
C4H4FN3O
Flucytosine RX_link
http://www.rxlist.com/cgi/generic3/flucytosine.htm
Flucytosine fda sheet
Flucytosine msds (material safety sheet)
Flucytosine Synthesis Reference
No information avaliable
Flucytosine Molecular Weight
129.093 g/mol
Flucytosine Melting Point
296 oC
Flucytosine H2O Solubility
10.5 g/L
Flucytosine State
Solid
Flucytosine LogP
-0.062
Flucytosine Dosage Forms
Capsule (250mg and 500mg)
Flucytosine Indication
For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).
Flucytosine Pharmacology
Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.
Flucytosine Absorption
Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.
Flucytosine side effects and Toxicity
Oral, rat: LD50 = >15 gm/kg.
Flucytosine Patient Information
Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis.
Flucytosine Organisms Affected
Yeast and other fungi
