5-Fluorocytosine
5-Fluorocytosine Brand names, 5-Fluorocytosine Analogs
5-Fluorocytosine Brand Names Mixture
- No information avaliable
5-Fluorocytosine Chemical_Formula
C4H4FN3O
5-Fluorocytosine RX_link
http://www.rxlist.com/cgi/generic3/flucytosine.htm
5-Fluorocytosine fda sheet
5-Fluorocytosine msds (material safety sheet)
5-Fluorocytosine Synthesis Reference
No information avaliable
5-Fluorocytosine Molecular Weight
129.093 g/mol
5-Fluorocytosine Melting Point
296 oC
5-Fluorocytosine H2O Solubility
10.5 g/L
5-Fluorocytosine State
Solid
5-Fluorocytosine LogP
-0.062
5-Fluorocytosine Dosage Forms
Capsule (250mg and 500mg)
5-Fluorocytosine Indication
For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).
5-Fluorocytosine Pharmacology
Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.
5-Fluorocytosine Absorption
Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.
5-Fluorocytosine side effects and Toxicity
Oral, rat: LD50 = >15 gm/kg.
5-Fluorocytosine Patient Information
Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis.
5-Fluorocytosine Organisms Affected
Yeast and other fungi
