Fluorcytosine

Fluorcytosine Brand names, Fluorcytosine Analogs

Fluorcytosine Brand Names Mixture

No information avaliable

Fluorcytosine Chemical_Formula

C₄H₄FN₃O

Fluorcytosine RX_link

http://www.rxlist.com/cgi/generic3/flucytosine.htm

Fluorcytosine fda sheet

Fluorcytosine FDA

Fluorcytosine msds (material safety sheet)

Fluorcytosine MSDS

Fluorcytosine Synthesis Reference

No information avaliable

Fluorcytosine Molecular Weight

129.093 g/mol

Fluorcytosine Melting Point

296 ^oC

Fluorcytosine H₂O Solubility

10.5 g/L

Fluorcytosine State

Solid

Fluorcytosine LogP

-0.062

Fluorcytosine Dosage Forms

Capsule (250mg and 500mg)

Fluorcytosine Indication

For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).

Fluorcytosine Pharmacology

Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.

Fluorcytosine Absorption

Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.

Fluorcytosine side effects and Toxicity

Oral, rat: LD₅₀ = >15 gm/kg.

Fluorcytosine Patient Information

Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis.

Fluorcytosine Organisms Affected

Yeast and other fungi