5-Fluorocystosine
5-Fluorocystosine Brand names, 5-Fluorocystosine Analogs
5-Fluorocystosine Brand Names Mixture
- No information avaliable
5-Fluorocystosine Chemical_Formula
C4H4FN3O
5-Fluorocystosine RX_link
http://www.rxlist.com/cgi/generic3/flucytosine.htm
5-Fluorocystosine fda sheet
5-Fluorocystosine msds (material safety sheet)
5-Fluorocystosine Synthesis Reference
No information avaliable
5-Fluorocystosine Molecular Weight
129.093 g/mol
5-Fluorocystosine Melting Point
296 oC
5-Fluorocystosine H2O Solubility
10.5 g/L
5-Fluorocystosine State
Solid
5-Fluorocystosine LogP
-0.062
5-Fluorocystosine Dosage Forms
Capsule (250mg and 500mg)
5-Fluorocystosine Indication
For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).
5-Fluorocystosine Pharmacology
Flucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. Antifungal synergism between Ancobon and polyene antibiotics, particularly amphotericin B, has been reported.
5-Fluorocystosine Absorption
Rapidly and virtually completely absorbed following oral administration. Bioavailability 78% to 89%.
5-Fluorocystosine side effects and Toxicity
Oral, rat: LD50 = >15 gm/kg.
5-Fluorocystosine Patient Information
Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis.
5-Fluorocystosine Organisms Affected
Yeast and other fungi
