Ethacrynic acid (USAN)
Ethacrynic acid (USAN) Brand names, Ethacrynic acid (USAN) Analogs
Ethacrynic acid (USAN) Brand Names Mixture
- No information avaliable
Ethacrynic acid (USAN) Chemical_Formula
C13H12Cl2O4
Ethacrynic acid (USAN) RX_link
http://www.rxlist.com/cgi/generic3/edecrin.htm
Ethacrynic acid (USAN) fda sheet
Ethacrynic acid (USAN) msds (material safety sheet)
Ethacrynic acid (USAN) Synthesis Reference
No information avaliable
Ethacrynic acid (USAN) Molecular Weight
303.137 g/mol
Ethacrynic acid (USAN) Melting Point
122.5 oC
Ethacrynic acid (USAN) H2O Solubility
No information avaliable
Ethacrynic acid (USAN) State
Solid
Ethacrynic acid (USAN) LogP
3.414
Ethacrynic acid (USAN) Dosage Forms
Tablet (25, 50 mg); Powder for solution
Ethacrynic acid (USAN) Indication
For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.
Ethacrynic acid (USAN) Pharmacology
Ethacrynic acid is a monosulfonamyl loop or high ceiling diuretic. Ethacrynic acid acts on the ascending limb of the loop of Henle and on the proximal and distal tubules. Urinary output is usually dose dependent and related to the magnitude of fluid accumulation. Water and electrolyte excretion may be increased several times over that observed with thiazide diuretics, since ethacrynic acid inhibits reabsorption of a much greater proportion of filtered sodium than most other diuretic agents. Therefore, ethacrynic acid is effective in many patients who have significant degrees of renal insufficiency. Ethacrynic acid has little or no effect on glomerular filtration or on renal blood flow, except following pronounced reductions in plasma volume when associated with rapid diuresis.
Ethacrynic acid (USAN) Absorption
Onset of action is rapid, usually within 30 minutes after an oral dose of ethacrynic acid or within 5 minutes after an intravenous injection of ethacrynic acid.
Ethacrynic acid (USAN) side effects and Toxicity
Overdosage may lead to excessive diuresis with electrolyte depletion.
Ethacrynic acid (USAN) Patient Information
No information avaliable
Ethacrynic acid (USAN) Organisms Affected
Humans and other mammals
