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Otacril Brand names, Otacril Analogs

Otacril Brand Names Mixture

  • No information avaliable

Otacril Chemical_Formula


Otacril RX_link


Otacril fda sheet

Otacril FDA

Otacril msds (material safety sheet)

Otacril MSDS

Otacril Synthesis Reference

No information avaliable

Otacril Molecular Weight

303.137 g/mol

Otacril Melting Point

122.5 oC

Otacril H2O Solubility

No information avaliable

Otacril State


Otacril LogP


Otacril Dosage Forms

Tablet (25, 50 mg); Powder for solution

Otacril Indication

For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.

Otacril Pharmacology

Ethacrynic acid is a monosulfonamyl loop or high ceiling diuretic. Ethacrynic acid acts on the ascending limb of the loop of Henle and on the proximal and distal tubules. Urinary output is usually dose dependent and related to the magnitude of fluid accumulation. Water and electrolyte excretion may be increased several times over that observed with thiazide diuretics, since ethacrynic acid inhibits reabsorption of a much greater proportion of filtered sodium than most other diuretic agents. Therefore, ethacrynic acid is effective in many patients who have significant degrees of renal insufficiency. Ethacrynic acid has little or no effect on glomerular filtration or on renal blood flow, except following pronounced reductions in plasma volume when associated with rapid diuresis.

Otacril Absorption

Onset of action is rapid, usually within 30 minutes after an oral dose of ethacrynic acid or within 5 minutes after an intravenous injection of ethacrynic acid.

Otacril side effects and Toxicity

Overdosage may lead to excessive diuresis with electrolyte depletion.

Otacril Patient Information

No information avaliable

Otacril Organisms Affected

Humans and other mammals