Droperidol
Droperidol Brand names, Droperidol Analogs
Droperidol Brand Names Mixture
- No information avaliable
Droperidol Chemical_Formula
C22H22FN3O2
Droperidol RX_link
http://www.rxlist.com/cgi/generic3/droperidol.htm
Droperidol fda sheet
Droperidol msds (material safety sheet)
Droperidol Synthesis Reference
No information avaliable
Droperidol Molecular Weight
379.428 g/mol
Droperidol Melting Point
145.75 oC
Droperidol H2O Solubility
4.21 mg/L
Droperidol State
Solid
Droperidol LogP
2.791
Droperidol Dosage Forms
Liquid; Solution
Droperidol Indication
Used to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
Droperidol Pharmacology
Droperidol produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness. Droperidol produces an antiemetic effect as evidenced by the antagonism of apomorphine in dogs. It lowers the incidence of nausea and vomiting during surgical procedures and provides antiemetic protection in the postoperative period. Droperidol potentiates other CNS depressants. It produces mild alpha-adrenergic blockade, peripheral vascular dilatation and reduction of the pressor effect of epinephrine. It can produce hypotension and decreased peripheral vascular resistance and may decrease pulmonary arterial pressure (particularly if it is abnormally high). It may reduce the incidence of epinephrine-induced arrhythmias, but it does not prevent other cardiac arrhythmias.
Droperidol Absorption
Completely absorbed following intramuscular administration.
Droperidol side effects and Toxicity
The intravenous LD50 of droperidol is 20-43 mg/kg in mice; 30 mg/kg in rats; 25 mg/kg in dogs and 11-13 mg/kg in rabbits. The intramuscular LD50 of droperidol is 195 mg/kg in mice, 104-110 mg/kg in rats; 97 mg/kg in rabbits and 200 mg/kg in guinea pigs. The manifestations of droperidol overdosage are an extension of its pharmacologic actions.
Droperidol Patient Information
Droperidol Organisms Affected
Humans and other mammals
