BH4
BH4 Brand names, BH4 Analogs
BH4 Brand Names Mixture
- No information avaliable
BH4 Chemical_Formula
C22H22FN3O2
BH4 RX_link
http://www.rxlist.com/cgi/generic3/droperidol.htm
BH4 fda sheet
BH4 msds (material safety sheet)
BH4 Synthesis Reference
No information avaliable
BH4 Molecular Weight
379.428 g/mol
BH4 Melting Point
145.75 oC
BH4 H2O Solubility
4.21 mg/L
BH4 State
Solid
BH4 LogP
2.791
BH4 Dosage Forms
Liquid; Solution
BH4 Indication
Used to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
BH4 Pharmacology
Droperidol produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness. Droperidol produces an antiemetic effect as evidenced by the antagonism of apomorphine in dogs. It lowers the incidence of nausea and vomiting during surgical procedures and provides antiemetic protection in the postoperative period. Droperidol potentiates other CNS depressants. It produces mild alpha-adrenergic blockade, peripheral vascular dilatation and reduction of the pressor effect of epinephrine. It can produce hypotension and decreased peripheral vascular resistance and may decrease pulmonary arterial pressure (particularly if it is abnormally high). It may reduce the incidence of epinephrine-induced arrhythmias, but it does not prevent other cardiac arrhythmias.
BH4 Absorption
Completely absorbed following intramuscular administration.
BH4 side effects and Toxicity
The intravenous LD50 of droperidol is 20-43 mg/kg in mice; 30 mg/kg in rats; 25 mg/kg in dogs and 11-13 mg/kg in rabbits. The intramuscular LD50 of droperidol is 195 mg/kg in mice, 104-110 mg/kg in rats; 97 mg/kg in rabbits and 200 mg/kg in guinea pigs. The manifestations of droperidol overdosage are an extension of its pharmacologic actions.
BH4 Patient Information
BH4 Organisms Affected
Humans and other mammals
