Sapropterin
Sapropterin Brand names, Sapropterin Analogs
Sapropterin Brand Names Mixture
- No information avaliable
Sapropterin Chemical_Formula
C22H22FN3O2
Sapropterin RX_link
http://www.rxlist.com/cgi/generic3/droperidol.htm
Sapropterin fda sheet
Sapropterin msds (material safety sheet)
Sapropterin Synthesis Reference
No information avaliable
Sapropterin Molecular Weight
379.428 g/mol
Sapropterin Melting Point
145.75 oC
Sapropterin H2O Solubility
4.21 mg/L
Sapropterin State
Solid
Sapropterin LogP
2.791
Sapropterin Dosage Forms
Liquid; Solution
Sapropterin Indication
Used to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
Sapropterin Pharmacology
Droperidol produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness. Droperidol produces an antiemetic effect as evidenced by the antagonism of apomorphine in dogs. It lowers the incidence of nausea and vomiting during surgical procedures and provides antiemetic protection in the postoperative period. Droperidol potentiates other CNS depressants. It produces mild alpha-adrenergic blockade, peripheral vascular dilatation and reduction of the pressor effect of epinephrine. It can produce hypotension and decreased peripheral vascular resistance and may decrease pulmonary arterial pressure (particularly if it is abnormally high). It may reduce the incidence of epinephrine-induced arrhythmias, but it does not prevent other cardiac arrhythmias.
Sapropterin Absorption
Completely absorbed following intramuscular administration.
Sapropterin side effects and Toxicity
The intravenous LD50 of droperidol is 20-43 mg/kg in mice; 30 mg/kg in rats; 25 mg/kg in dogs and 11-13 mg/kg in rabbits. The intramuscular LD50 of droperidol is 195 mg/kg in mice, 104-110 mg/kg in rats; 97 mg/kg in rabbits and 200 mg/kg in guinea pigs. The manifestations of droperidol overdosage are an extension of its pharmacologic actions.
Sapropterin Patient Information
Sapropterin Organisms Affected
Humans and other mammals
