Dapropterin
Dapropterin Brand names, Dapropterin Analogs
Dapropterin Brand Names Mixture
- No information avaliable
Dapropterin Chemical_Formula
C22H22FN3O2
Dapropterin RX_link
http://www.rxlist.com/cgi/generic3/droperidol.htm
Dapropterin fda sheet
Dapropterin msds (material safety sheet)
Dapropterin Synthesis Reference
No information avaliable
Dapropterin Molecular Weight
379.428 g/mol
Dapropterin Melting Point
145.75 oC
Dapropterin H2O Solubility
4.21 mg/L
Dapropterin State
Solid
Dapropterin LogP
2.791
Dapropterin Dosage Forms
Liquid; Solution
Dapropterin Indication
Used to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
Dapropterin Pharmacology
Droperidol produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness. Droperidol produces an antiemetic effect as evidenced by the antagonism of apomorphine in dogs. It lowers the incidence of nausea and vomiting during surgical procedures and provides antiemetic protection in the postoperative period. Droperidol potentiates other CNS depressants. It produces mild alpha-adrenergic blockade, peripheral vascular dilatation and reduction of the pressor effect of epinephrine. It can produce hypotension and decreased peripheral vascular resistance and may decrease pulmonary arterial pressure (particularly if it is abnormally high). It may reduce the incidence of epinephrine-induced arrhythmias, but it does not prevent other cardiac arrhythmias.
Dapropterin Absorption
Completely absorbed following intramuscular administration.
Dapropterin side effects and Toxicity
The intravenous LD50 of droperidol is 20-43 mg/kg in mice; 30 mg/kg in rats; 25 mg/kg in dogs and 11-13 mg/kg in rabbits. The intramuscular LD50 of droperidol is 195 mg/kg in mice, 104-110 mg/kg in rats; 97 mg/kg in rabbits and 200 mg/kg in guinea pigs. The manifestations of droperidol overdosage are an extension of its pharmacologic actions.
Dapropterin Patient Information
Dapropterin Organisms Affected
Humans and other mammals
