Dinoprostone

Dinoprostone Brand names, Dinoprostone Analogs

Dinoprostone Brand Names Mixture

No information avaliable

Dinoprostone Chemical_Formula

C₂₀H₃₂O₅

Dinoprostone RX_link

http://www.rxlist.com/cgi/generic2/dinoprostone.htm

Dinoprostone fda sheet

Dinoprostone msds (material safety sheet)

Dinoprostone MSDS

Dinoprostone Synthesis Reference

No information avaliable

Dinoprostone Molecular Weight

352.465 g/mol

Dinoprostone Melting Point

67 ^oC

Dinoprostone H₂O Solubility

58.1 mg/L

Dinoprostone State

Solid

Dinoprostone LogP

1.949

Dinoprostone Dosage Forms

Gel; Insert (suppository containing 20 mg of dinoprostone); Tablet

Dinoprostone Indication

For the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period. Also for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period, and also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).

Dinoprostone Pharmacology

Dinoprostone is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery and thus terminates pregnancy. Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.

Dinoprostone Absorption

Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.

Dinoprostone side effects and Toxicity

Oral, mouse: LD₅₀ = 750 mg/kg; Oral, rat: LD₅₀ = 500 mg/kg.

Dinoprostone Patient Information