Prostarmon E
Brand names,
Prostarmon E
Analogs
Prostarmon E
Brand Names Mixture
Prostarmon E
Chemical_Formula
C20H32O5
Prostarmon E
RX_link
http://www.rxlist.com/cgi/generic2/dinoprostone.htm
Prostarmon E
fda sheet
Prostarmon E
msds (material safety sheet)
Prostarmon E
Synthesis Reference
No information avaliable
Prostarmon E
Molecular Weight
352.465 g/mol
Prostarmon E
Melting Point
67 oC
Prostarmon E
H2O Solubility
58.1 mg/L
Prostarmon E
State
Solid
Prostarmon E
LogP
1.949
Prostarmon E
Dosage Forms
Gel; Insert (suppository containing 20 mg of dinoprostone); Tablet
Prostarmon E
Indication
For the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period. Also for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period, and also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).
Prostarmon E
Pharmacology
Dinoprostone is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery and thus terminates pregnancy. Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.
Prostarmon E
Absorption
Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.
Prostarmon E
side effects and Toxicity
Oral, mouse: LD50 = 750 mg/kg; Oral, rat: LD50 = 500 mg/kg.
Prostarmon E
Patient Information
No information avaliable
Prostarmon E
Organisms Affected
Humans and other mammals