PGE2

• Oxytocics
• Prostaglandins
• ATC:G02AD02

• Cervidil
• Dinoprostone Prostaglandin E2
• PGE2
• Prepidil
• Prostaglandin E2
• Prostarmon E
• Prostin E
• Prostin E2

• No information avaliable

C₂₀H₃₂O₅

http://www.rxlist.com/cgi/generic2/dinoprostone.htm

PGE2 MSDS

No information avaliable

352.465 g/mol

67 ^oC

58.1 mg/L

Solid

1.949

Gel; Insert (suppository containing 20 mg of dinoprostone); Tablet

For the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period. Also for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period, and also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).

Dinoprostone is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery and thus terminates pregnancy. Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.

Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.

Oral, mouse: LD₅₀ = 750 mg/kg; Oral, rat: LD₅₀ = 500 mg/kg.

No information avaliable

Humans and other mammals