PGE2

PGE2 Brand names, PGE2 Analogs

PGE2 Brand Names Mixture

No information avaliable

PGE2 Chemical_Formula

C₂₀H₃₂O₅

PGE2 RX_link

http://www.rxlist.com/cgi/generic2/dinoprostone.htm

PGE2 fda sheet

PGE2 msds (material safety sheet)

PGE2 MSDS

PGE2 Synthesis Reference

No information avaliable

PGE2 Molecular Weight

352.465 g/mol

PGE2 Melting Point

67 ^oC

PGE2 H₂O Solubility

58.1 mg/L

PGE2 State

Solid

PGE2 LogP

1.949

PGE2 Dosage Forms

Gel; Insert (suppository containing 20 mg of dinoprostone); Tablet

PGE2 Indication

For the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period. Also for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period, and also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).

PGE2 Pharmacology

Dinoprostone is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery and thus terminates pregnancy. Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.

PGE2 Absorption

Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.

PGE2 side effects and Toxicity

Oral, mouse: LD₅₀ = 750 mg/kg; Oral, rat: LD₅₀ = 500 mg/kg.

PGE2 Patient Information