Prostaglandin E2

Prostaglandin E2 Brand names, Prostaglandin E2 Analogs

Prostaglandin E2 Brand Names Mixture

No information avaliable

Prostaglandin E2 Chemical_Formula

C₂₀H₃₂O₅

Prostaglandin E2 RX_link

http://www.rxlist.com/cgi/generic2/dinoprostone.htm

Prostaglandin E2 fda sheet

Prostaglandin E2 msds (material safety sheet)

Prostaglandin_E2 MSDS

Prostaglandin E2 Synthesis Reference

No information avaliable

Prostaglandin E2 Molecular Weight

352.465 g/mol

Prostaglandin E2 Melting Point

67 ^oC

Prostaglandin E2 H₂O Solubility

58.1 mg/L

Prostaglandin E2 State

Solid

Prostaglandin E2 LogP

1.949

Prostaglandin E2 Dosage Forms

Gel; Insert (suppository containing 20 mg of dinoprostone); Tablet

Prostaglandin E2 Indication

For the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period. Also for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period, and also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).

Prostaglandin E2 Pharmacology

Dinoprostone is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery and thus terminates pregnancy. Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.

Prostaglandin E2 Absorption

Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.

Prostaglandin E2 side effects and Toxicity

Oral, mouse: LD₅₀ = 750 mg/kg; Oral, rat: LD₅₀ = 500 mg/kg.

Prostaglandin E2 Patient Information