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Cyclophosphoramide Brand names, Cyclophosphoramide Analogs

Cyclophosphoramide Brand Names Mixture

  • Procytox for Injection 2000mg Pws Iv (Cyclophosphamide + Sodium Chloride)

Cyclophosphoramide Chemical_Formula


Cyclophosphoramide RX_link

Cyclophosphoramide fda sheet

Cyclophosphoramide msds (material safety sheet)

Cyclophosphoramide MSDS

Cyclophosphoramide Synthesis Reference

Arnold et al, Angew.Chem., 70; 539; 543(1958)

Cyclophosphoramide Molecular Weight

261.085 g/mol

Cyclophosphoramide Melting Point

41-45 oC

Cyclophosphoramide H2O Solubility

Soluble. 1-5 g/100 mL at 23 oC

Cyclophosphoramide State


Cyclophosphoramide LogP

No information avaliable

Cyclophosphoramide Dosage Forms

Oral tablets; Oral liquid; Parenteral solution

Cyclophosphoramide Indication

For management of malignant lymphomas, multiple myeloma,leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma and carcinoma of the breast

Cyclophosphoramide Pharmacology

Cyclophosphamide is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Cyclophosphoramide Absorption


Cyclophosphoramide side effects and Toxicity

infection, myelosuppression, and cardiac toxicity

Cyclophosphoramide Patient Information

This medicine is a type of chemotherapy for treating cancers of the blood
and certain other cancers. This medicine interferes with the way cancer
cells grow. Take your doses on a regular scheduled time and DO NOT take
this medicine more often than directed by your health care provider.
Finish the full course prescribed by your health care provider. DO NOT
stop taking this medicine unless diredted to do so by your health care
provider. While taking this medicine, you make get infection more easily.
Call your doctor if you get a fever, chills, or sore throat. Drink plenty
of water with this medicine.

Cyclophosphoramide Organisms Affected

Humans and other mammals