Cyclophosphamidum
Cyclophosphamidum Brand names, Cyclophosphamidum Analogs
- ASTA
- Asta B 518
- CP
- CPA
- CTX
- CY
- Clafen
- Claphene
- Cyclophosphamid
- Cyclophosphamide Monohydrate
- Cyclophosphamide Sterile
- Cyclophosphamidum
- Cyclophosphan
- Cyclophosphane
- Cyclophosphoramide
- Cyclostin
- Cyklofosfamid
- Cytophosphan
- Cytoxan
- Cytoxan Lyoph
- Endoxan
- Endoxan R
- Endoxan-Asta
- Endoxana
- Endoxanal
- Endoxane
- Enduxan
- Genoxal
- Hexadrin
- Lyophilized Cytoxan
- Mitoxan
- Neosar
- Procytox
- Rcra Waste Number U058
- Semdoxan
- Sendoxan
- Senduxan
- Zyklophosphamid
Cyclophosphamidum Brand Names Mixture
- Procytox for Injection 2000mg Pws Iv (Cyclophosphamide + Sodium Chloride)
Cyclophosphamidum Chemical_Formula
C7H15Cl2N2O2P
Cyclophosphamidum RX_link
http://www.rxlist.com/cgi/generic3/cyclophosphamide.htm
Cyclophosphamidum fda sheet
Cyclophosphamidum msds (material safety sheet)
Cyclophosphamidum Synthesis Reference
Arnold et al, Angew.Chem., 70; 539; 543(1958)
Cyclophosphamidum Molecular Weight
261.085 g/mol
Cyclophosphamidum Melting Point
41-45 oC
Cyclophosphamidum H2O Solubility
Soluble. 1-5 g/100 mL at 23 oC
Cyclophosphamidum State
solid
Cyclophosphamidum LogP
No information avaliable
Cyclophosphamidum Dosage Forms
Oral tablets; Oral liquid; Parenteral solution
Cyclophosphamidum Indication
For management of malignant lymphomas, multiple myeloma,leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma and carcinoma of the breast
Cyclophosphamidum Pharmacology
Cyclophosphamide is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Cyclophosphamidum Absorption
90-100%
Cyclophosphamidum side effects and Toxicity
infection, myelosuppression, and cardiac toxicity
Cyclophosphamidum Patient Information
This medicine is a type of chemotherapy for treating cancers of the blood
and certain other cancers. This medicine interferes with the way cancer
cells grow. Take your doses on a regular scheduled time and DO NOT take
this medicine more often than directed by your health care provider.
Finish the full course prescribed by your health care provider. DO NOT
stop taking this medicine unless diredted to do so by your health care
provider. While taking this medicine, you make get infection more easily.
Call your doctor if you get a fever, chills, or sore throat. Drink plenty
of water with this medicine.
and certain other cancers. This medicine interferes with the way cancer
cells grow. Take your doses on a regular scheduled time and DO NOT take
this medicine more often than directed by your health care provider.
Finish the full course prescribed by your health care provider. DO NOT
stop taking this medicine unless diredted to do so by your health care
provider. While taking this medicine, you make get infection more easily.
Call your doctor if you get a fever, chills, or sore throat. Drink plenty
of water with this medicine.
Cyclophosphamidum Organisms Affected
Humans and other mammals
