Coly-mycin M
Coly-mycin M Brand names, Coly-mycin M Analogs
Coly-mycin M Brand Names Mixture
- No information avaliable
Coly-mycin M Chemical_Formula
C32H52Br2N4O4
Coly-mycin M RX_link
http://www.rxlist.com/cgi/generic2/demecarium.htm
Coly-mycin M fda sheet
Coly-mycin M msds (material safety sheet)
Coly-mycin M Synthesis Reference
No information avaliable
Coly-mycin M Molecular Weight
716.588 g/mol
Coly-mycin M Melting Point
No information avaliable
Coly-mycin M H2O Solubility
No information avaliable
Coly-mycin M State
Solid
Coly-mycin M LogP
-1.75
Coly-mycin M Dosage Forms
Solution (drops - 0.125% and 0.25%)
Coly-mycin M Indication
For the topical treatment of chronic open-angle glaucoma.
Coly-mycin M Pharmacology
Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug.
Coly-mycin M Absorption
No information avaliable
Coly-mycin M side effects and Toxicity
The oral LD50 is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.
Coly-mycin M Patient Information
No information avaliable
Coly-mycin M Organisms Affected
Humans and other mammals
