Coly-mycin M en es it fr

Coly-mycin M Brand names, Coly-mycin M Analogs

Coly-mycin M Brand Names Mixture

  • No information avaliable

Coly-mycin M Chemical_Formula


Coly-mycin M RX_link

Coly-mycin M fda sheet

Coly-mycin M msds (material safety sheet)

Coly-mycin M Synthesis Reference

No information avaliable

Coly-mycin M Molecular Weight

716.588 g/mol

Coly-mycin M Melting Point

No information avaliable

Coly-mycin M H2O Solubility

No information avaliable

Coly-mycin M State


Coly-mycin M LogP


Coly-mycin M Dosage Forms

Solution (drops - 0.125% and 0.25%)

Coly-mycin M Indication

For the topical treatment of chronic open-angle glaucoma.

Coly-mycin M Pharmacology

Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug.

Coly-mycin M Absorption

No information avaliable

Coly-mycin M side effects and Toxicity

The oral LD50 is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.

Coly-mycin M Patient Information

No information avaliable

Coly-mycin M Organisms Affected

Humans and other mammals