Colistimethale Sodium
Colistimethale Sodium Brand names, Colistimethale Sodium Analogs
Colistimethale Sodium Brand Names Mixture
- No information avaliable
Colistimethale Sodium Chemical_Formula
C32H52Br2N4O4
Colistimethale Sodium RX_link
http://www.rxlist.com/cgi/generic2/demecarium.htm
Colistimethale Sodium fda sheet
Colistimethale Sodium msds (material safety sheet)
Colistimethale Sodium Synthesis Reference
No information avaliable
Colistimethale Sodium Molecular Weight
716.588 g/mol
Colistimethale Sodium Melting Point
No information avaliable
Colistimethale Sodium H2O Solubility
No information avaliable
Colistimethale Sodium State
Solid
Colistimethale Sodium LogP
-1.75
Colistimethale Sodium Dosage Forms
Solution (drops - 0.125% and 0.25%)
Colistimethale Sodium Indication
For the topical treatment of chronic open-angle glaucoma.
Colistimethale Sodium Pharmacology
Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug.
Colistimethale Sodium Absorption
No information avaliable
Colistimethale Sodium side effects and Toxicity
The oral LD50 is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.
Colistimethale Sodium Patient Information
No information avaliable
Colistimethale Sodium Organisms Affected
Humans and other mammals
