Colistin sodium methanesulfonate from bacillus colistinus
Colistin sodium methanesulfonate from bacillus colistinus Brand names, Colistin sodium methanesulfonate from bacillus colistinus Analogs
Colistin sodium methanesulfonate from bacillus colistinus Brand Names Mixture
- No information avaliable
Colistin sodium methanesulfonate from bacillus colistinus Chemical_Formula
C32H52Br2N4O4
Colistin sodium methanesulfonate from bacillus colistinus RX_link
http://www.rxlist.com/cgi/generic2/demecarium.htm
Colistin sodium methanesulfonate from bacillus colistinus fda sheet
Colistin sodium methanesulfonate from bacillus colistinus msds (material safety sheet)
Colistin sodium methanesulfonate from bacillus colistinus Synthesis Reference
No information avaliable
Colistin sodium methanesulfonate from bacillus colistinus Molecular Weight
716.588 g/mol
Colistin sodium methanesulfonate from bacillus colistinus Melting Point
No information avaliable
Colistin sodium methanesulfonate from bacillus colistinus H2O Solubility
No information avaliable
Colistin sodium methanesulfonate from bacillus colistinus State
Solid
Colistin sodium methanesulfonate from bacillus colistinus LogP
-1.75
Colistin sodium methanesulfonate from bacillus colistinus Dosage Forms
Solution (drops - 0.125% and 0.25%)
Colistin sodium methanesulfonate from bacillus colistinus Indication
For the topical treatment of chronic open-angle glaucoma.
Colistin sodium methanesulfonate from bacillus colistinus Pharmacology
Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug.
Colistin sodium methanesulfonate from bacillus colistinus Absorption
No information avaliable
Colistin sodium methanesulfonate from bacillus colistinus side effects and Toxicity
The oral LD50 is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.
Colistin sodium methanesulfonate from bacillus colistinus Patient Information
No information avaliable
Colistin sodium methanesulfonate from bacillus colistinus Organisms Affected
Humans and other mammals
