Colistin sodium methanesulfonate
Colistin sodium methanesulfonate Brand names, Colistin sodium methanesulfonate Analogs
Colistin sodium methanesulfonate Brand Names Mixture
- No information avaliable
Colistin sodium methanesulfonate Chemical_Formula
C32H52Br2N4O4
Colistin sodium methanesulfonate RX_link
http://www.rxlist.com/cgi/generic2/demecarium.htm
Colistin sodium methanesulfonate fda sheet
Colistin sodium methanesulfonate msds (material safety sheet)
Colistin sodium methanesulfonate Synthesis Reference
No information avaliable
Colistin sodium methanesulfonate Molecular Weight
716.588 g/mol
Colistin sodium methanesulfonate Melting Point
No information avaliable
Colistin sodium methanesulfonate H2O Solubility
No information avaliable
Colistin sodium methanesulfonate State
Solid
Colistin sodium methanesulfonate LogP
-1.75
Colistin sodium methanesulfonate Dosage Forms
Solution (drops - 0.125% and 0.25%)
Colistin sodium methanesulfonate Indication
For the topical treatment of chronic open-angle glaucoma.
Colistin sodium methanesulfonate Pharmacology
Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug.
Colistin sodium methanesulfonate Absorption
No information avaliable
Colistin sodium methanesulfonate side effects and Toxicity
The oral LD50 is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.
Colistin sodium methanesulfonate Patient Information
No information avaliable
Colistin sodium methanesulfonate Organisms Affected
Humans and other mammals
