Colistimethate sodium
Colistimethate sodium Brand names, Colistimethate sodium Analogs
Colistimethate sodium Brand Names Mixture
- No information avaliable
Colistimethate sodium Chemical_Formula
C32H52Br2N4O4
Colistimethate sodium RX_link
http://www.rxlist.com/cgi/generic2/demecarium.htm
Colistimethate sodium fda sheet
Colistimethate sodium msds (material safety sheet)
Colistimethate sodium Synthesis Reference
No information avaliable
Colistimethate sodium Molecular Weight
716.588 g/mol
Colistimethate sodium Melting Point
No information avaliable
Colistimethate sodium H2O Solubility
No information avaliable
Colistimethate sodium State
Solid
Colistimethate sodium LogP
-1.75
Colistimethate sodium Dosage Forms
Solution (drops - 0.125% and 0.25%)
Colistimethate sodium Indication
For the topical treatment of chronic open-angle glaucoma.
Colistimethate sodium Pharmacology
Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle contraction due to inhibition of cholinesterase, allowing acetylcholine to accumulate at sites of cholinergic transmission. These effects are accompanied by increased capillary permeability of the ciliary body and iris, increased permeability of the blood-aqueous barrier, and vasodilation. Myopia may be induced or, if present, may be augmented by the increased refractive power of the lens that results from the accommodative effect of the drug.
Colistimethate sodium Absorption
No information avaliable
Colistimethate sodium side effects and Toxicity
The oral LD50 is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities.
Colistimethate sodium Patient Information
No information avaliable
Colistimethate sodium Organisms Affected
Humans and other mammals
