PharmacyCodes



Clonidine en es it fr

Clonidine Brand names, Clonidine Analogs

Clonidine Brand Names Mixture

  • Combipres 0.1/15 Tab (Chlorthalidone + Clonidine Hydrochloride)

Clonidine Chemical_Formula

C9H9Cl2N3

Clonidine RX_link

http://www.rxlist.com/cgi/generic/clonidin.htm

Clonidine fda sheet

Clonidine msds (material safety sheet)

Clonidine MSDS

Clonidine Synthesis Reference

Zeile et al.; U.S. Pat. 3,202,660(1965)

Clonidine Molecular Weight

230.093 g/mol

Clonidine Melting Point

130oC

Clonidine H2O Solubility

Appreciable

Clonidine State

Solid

Clonidine LogP

2.278

Clonidine Dosage Forms

Tablet; Patch

Clonidine Indication

For the treatment of hypertension and maybe used in prophylaxis of migraine or recurrent vascular headache; Menopausal flushing

Clonidine Pharmacology

Clonidine is an antihypertensive agent and an epidural agent for refractory cancer pain. Similar to guanabenz in mechanism of action, clonidine is used in the treatment of hypertension, opiate and nicotine withdrawal, vascular headaches, diabetic diarrhea, glaucoma, ulcerative colitis, Gilles de la Tourette's syndrome, menopause symptoms, severe pain in cancer patients refractory to opiate agonists, and neuropathic pain and in the diagnosis of pheochromocytoma.

Clonidine Absorption

Well absorbed following oral administration. Bioavailability following chronic administration is approximately 65%.

Clonidine side effects and Toxicity

Oral LD50 is 150 mg/kg in rat and 30 mg/kg in dog. Symptoms of overdose include constriction of pupils of the eye, drowsiness, high blood pressure followed by a drop in pressure, irritability, low body temperature, slowed breathing, slowed heartbeat, slowed reflexes, and weakness.

Clonidine Patient Information

Tablet

Patients who engage in potentially hazardous activities, such as operating machinery or driving, should be advised of a potential sedative effect of clonidine. Patients should be cautioned against interruption of clonidine hydrochloride therapy without a physician's advice.

Epidural Injection

Patients should be instructed about the risks of rebound hypertension and warned not to discontinue clonidine except under the supervision of a physician. Patients should notify their physician immediately if clonidine administration is inadvertently interrupted for any reason. Patients who engage in potentially hazardous activities, such as operating machinery or driving, should be advised of the potential sedative and hypotensive effects of epidural clonidine. They should also be informed that sedative effects may be increased by CNS-depressing drugs such as alcohol and barbiturates, and that hypotensive effects may be increased by opiates.

Clonidine Organisms Affected

Humans and other mammals