Duraclont

Duraclont Brand names, Duraclont Analogs

Duraclont Brand Names Mixture

Combipres 0.1/15 Tab (Chlorthalidone + Clonidine Hydrochloride)

Duraclont Chemical_Formula

C₉H₉Cl₂N₃

Duraclont RX_link

http://www.rxlist.com/cgi/generic/clonidin.htm

Duraclont fda sheet

Duraclont msds (material safety sheet)

Duraclont MSDS

Duraclont Synthesis Reference

Zeile et al.; U.S. Pat. 3,202,660(1965)

Duraclont Molecular Weight

230.093 g/mol

Duraclont Melting Point

130^oC

Duraclont H₂O Solubility

Appreciable

Duraclont State

Solid

Duraclont LogP

2.278

Duraclont Dosage Forms

Tablet; Patch

Duraclont Indication

For the treatment of hypertension and maybe used in prophylaxis of migraine or recurrent vascular headache; Menopausal flushing

Duraclont Pharmacology

Clonidine is an antihypertensive agent and an epidural agent for refractory cancer pain. Similar to guanabenz in mechanism of action, clonidine is used in the treatment of hypertension, opiate and nicotine withdrawal, vascular headaches, diabetic diarrhea, glaucoma, ulcerative colitis, Gilles de la Tourette's syndrome, menopause symptoms, severe pain in cancer patients refractory to opiate agonists, and neuropathic pain and in the diagnosis of pheochromocytoma.

Duraclont Absorption

Well absorbed following oral administration. Bioavailability following chronic administration is approximately 65%.

Duraclont side effects and Toxicity

Oral LD50 is 150 mg/kg in rat and 30 mg/kg in dog. Symptoms of overdose include constriction of pupils of the eye, drowsiness, high blood pressure followed by a drop in pressure, irritability, low body temperature, slowed breathing, slowed heartbeat, slowed reflexes, and weakness.

Duraclont Patient Information

Tablet

Patients who engage in potentially hazardous activities, such as operating machinery or driving, should be advised of a potential sedative effect of clonidine. Patients should be cautioned against interruption of clonidine hydrochloride therapy without a physician's advice.

Epidural Injection

Patients should be instructed about the risks of rebound hypertension and warned not to discontinue clonidine except under the supervision of a physician. Patients should notify their physician immediately if clonidine administration is inadvertently interrupted for any reason. Patients who engage in potentially hazardous activities, such as operating machinery or driving, should be advised of the potential sedative and hypotensive effects of epidural clonidine. They should also be informed that sedative effects may be increased by CNS-depressing drugs such as alcohol and barbiturates, and that hypotensive effects may be increased by opiates.

Duraclont Organisms Affected

Humans and other mammals