Adesipress

Adesipress Brand names, Adesipress Analogs

Adesipress Brand Names Mixture

Combipres 0.1/15 Tab (Chlorthalidone + Clonidine Hydrochloride)

Adesipress Chemical_Formula

C₉H₉Cl₂N₃

Adesipress RX_link

http://www.rxlist.com/cgi/generic/clonidin.htm

Adesipress fda sheet

Adesipress msds (material safety sheet)

Adesipress MSDS

Adesipress Synthesis Reference

Zeile et al.; U.S. Pat. 3,202,660(1965)

Adesipress Molecular Weight

230.093 g/mol

Adesipress Melting Point

130^oC

Adesipress H₂O Solubility

Appreciable

Adesipress State

Solid

Adesipress LogP

2.278

Adesipress Dosage Forms

Tablet; Patch

Adesipress Indication

For the treatment of hypertension and maybe used in prophylaxis of migraine or recurrent vascular headache; Menopausal flushing

Adesipress Pharmacology

Clonidine is an antihypertensive agent and an epidural agent for refractory cancer pain. Similar to guanabenz in mechanism of action, clonidine is used in the treatment of hypertension, opiate and nicotine withdrawal, vascular headaches, diabetic diarrhea, glaucoma, ulcerative colitis, Gilles de la Tourette's syndrome, menopause symptoms, severe pain in cancer patients refractory to opiate agonists, and neuropathic pain and in the diagnosis of pheochromocytoma.

Adesipress Absorption

Well absorbed following oral administration. Bioavailability following chronic administration is approximately 65%.

Adesipress side effects and Toxicity

Oral LD50 is 150 mg/kg in rat and 30 mg/kg in dog. Symptoms of overdose include constriction of pupils of the eye, drowsiness, high blood pressure followed by a drop in pressure, irritability, low body temperature, slowed breathing, slowed heartbeat, slowed reflexes, and weakness.

Adesipress Patient Information

Tablet

Patients who engage in potentially hazardous activities, such as operating machinery or driving, should be advised of a potential sedative effect of clonidine. Patients should be cautioned against interruption of clonidine hydrochloride therapy without a physician's advice.

Epidural Injection

Patients should be instructed about the risks of rebound hypertension and warned not to discontinue clonidine except under the supervision of a physician. Patients should notify their physician immediately if clonidine administration is inadvertently interrupted for any reason. Patients who engage in potentially hazardous activities, such as operating machinery or driving, should be advised of the potential sedative and hypotensive effects of epidural clonidine. They should also be informed that sedative effects may be increased by CNS-depressing drugs such as alcohol and barbiturates, and that hypotensive effects may be increased by opiates.

Adesipress Organisms Affected

Humans and other mammals