Betamethasone

Betamethasone Brand names, Betamethasone Analogs

Betamethasone Brand Names Mixture

Lotrisone (betamethasone + clotrimazole)

Betamethasone Chemical_Formula

C₂₂H₂₉FO₅

Betamethasone RX_link

http://www.rxlist.com/cgi/generic2/betamet.htm

Betamethasone fda sheet

Betamethasone FDA

Betamethasone msds (material safety sheet)

Betamethasone MSDS

Betamethasone Synthesis Reference

Taub et al., J. Am. Chem. Soc. 80, 4435 (1958)

Betamethasone Molecular Weight

392.461 g/mol

Betamethasone Melting Point

231-234^oC

Betamethasone H₂O Solubility

Insoluble

Betamethasone State

Solid

Betamethasone LogP

1.772

Betamethasone Dosage Forms

Oral Solution; Tablet; Solution for Injection; Injectable Suspension; Cream; Gel; Ointment; Foam; Lotion

Betamethasone Indication

Topical use (cream, lotion and ointment): for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Topical use (foam): relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp
Systemic use: for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis.

Betamethasone Pharmacology

Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections.

Betamethasone Absorption

Minimal if applied topically.

Betamethasone side effects and Toxicity

Symptoms of overdose include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.

Betamethasone Patient Information

Patients using topical corticosteroids should receive the following information and instructions. This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

1. This medication is to be used as directed by the physician and should not be used longer than the prescribed time period. It is for external use only. Avoid contact with the eyes.

2. Patients should be advised not to use this medication for any disorder other than that for which it was prescribed.

3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive.

4. Patients should report any signs of local adverse reactions.

5. Other corticosteroid-containing products should not be used with DIPROLENE AF Cream without first talking to your physician.

Betamethasone Organisms Affected

Humans and other mammals